My Blog
Home page > My Blog > Parental consanguinity on north France

Parental consanguinity on north France

Monday 27 February 2012, by Admin

The risk for birth defects in the offspring of first-cousin matings has been estimated to increase sharply compared to non consanguineous marriages.

As a general decline in the frequency of consanguineous marriages was observed in this century, one wonders whether consanguinity is still a factor in the appearance of birth defects in developed countries.

Based on our registry of congenital anomalies we tried to answer to this question.

In the population studied in North France a consanguineous mating was known in 68.21% of the cases with congenital anomalies, vs. 0.27% in controls, (p < 0.001). The frequency of the malformations recorded paralleled the degree of consanguinity: out of 1000 malformed children, 451 were seen in first-cousins mating (84.3 times more frequent than in offspring of non consanguineous couples), 317 in second-cousins marriages and 232 in more distant relatives mating. Three were uncle-niece marriage.

Excluding known mendelian conditions these numbers were 942, 442, 283 and 217 respectively.

Therefore there is a negative dose-response effect between level of inbreeding and risk of congenital malformations.

Consanguineous mothers were more often pregnant than non consanguineous mothers (p < 0.01) and they had more stillbirths than non consanguineous mothers.

These results show that consanguinity is still a factor of birth defects and they must be taken into account for genetic counseling of inbred marriages, in developed France’s regions.

2 Forum messages

  • Heyyy 27 February 2012 10:57, by Friendly-Boy

    Hii dude,

    did u remember to made a backup of ur site for the migration ?

    • Heyyy 27 February 2012 10:59, by Admin

      fine, fine and u ?

      yes ive made the backup yesterday.

SPIP | template | | Site Map | Follow-up of the site's activity RSS 2.0